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Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milkDetectable amounts of estrogens have been identified in the milk of mothers receiving this drugCaution should be exercised when Estrace is administered to a nursing woman.

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flowbreakthrough bleedingspottingdysmenorrhea.

15Crane MGHarris JJWinsor W 3dHypertensionoral contraceptive agentsand conjugated estrogensAnn Intern Med 74197113-21.

Because estrogens may cause some degree of fluid retentionpatients with conditions that might be influenced by this factorsuch as asthmaepilepsymigraineand cardiac or renal dysfunctionwarrant careful observation when estrogens are prescribed.

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